156991-64-9Relevant academic research and scientific papers
Synthesis of enantiomerically pure bicyclic lactams
Diedrichs, Nicole,Westermann, Bernhard
, p. 1127 - 1129 (1999)
Enantiomerically pure homologous 1-azabicyclo-[x.y.0]alkanones (x = 4-5, y = 4-7) can be synthesized by ring closing olefin metathesis using Grubbs' ruthenium catalyst. By starting from monocyclic lactams, the bicyclic products, even eight- and nine-membered rings, are formed in high yields. The monocyclic lactames can be obtained enantiomerically pure by enzyme-catalyzed kinetic resolution.
