157-48-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Oxaspiro[2.3]hexane is used as a reactant for the preparation of spiro γ-lactones via aluminum enolate-spiro epoxide openings. These spiro γ-lactones are valuable intermediates in the synthesis of various pharmaceutical compounds, including those with potential therapeutic applications.
Used in Chemical Synthesis:
1-Oxaspiro[2.3]hexane serves as a versatile building block in the synthesis of complex organic molecules. Its unique spirocycle structure allows for the creation of a wide range of compounds with diverse properties and potential applications in various industries, such as materials science, agrochemicals, and specialty chemicals.

Upstream product

• 98070-78-1 1-chloromethyl-cyclobutanol 
• 1120-56-5 methylidenecyclobutane 
• 1191-95-3 cyclobutanone 
• 1774-47-6 trimethylsulfoxonium iodide 

Downstream Products

• 1120-56-5 methylidenecyclobutane 

Relevant academic research and scientific papers

NON-FUSED TRICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

OXYSTEROLS AND METHODS OF USE THEREOF

Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

PHARMACOLOGICALLY ACTIVE COMPOUNDS

The present invention relates to compounds of formula (II) wherein X, Y, R2, R3, R4 and Ar are all as defined herein. The compounds of the present invention are known to inhibit the spindle checkpoint function of Monospindle 1 (Mps1 – also known as TTK) kinases either directly or indirectly via interaction with the Mps1 kinase itself. In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

PYRAZOLYL DERIVATIVES AS SYK INHIBITORS

The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF

The present invention relates to thiazolidinylidene containing compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, and X are as defined in the specification, compositions comprising su

METHYLENECYCLOALKANES. STRAIN AND PROPERTIES

The synthesis of methylenecycloalkanes and of epoxides based on them was studied.The role of angular strain in the electron density distribution and the reactivity of the alkenes was investigated by quantum-chemical calculation by the LCAO-MO SCF method in the MINDO/3 valence approximation.The data from the calculation are compared with the spectral and kinetic parameters of the epoxidation of methylene-cycloalkanes by peracetic acid in ethyl acetate.