1570-67-8

Basic information

• Product Name: 2,6-Dichloro-3,4-dimethylphenol
• Synonyms: 2,6-Dichloro-3,4-dimethylphenol
• CAS NO: 1570-67-8
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.06
• Mol File: 1570-67-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,6-Dichloro-3,4-dimethylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-3,4-dimethylphenol(1570-67-8)
• EPA Substance Registry System: 2,6-Dichloro-3,4-dimethylphenol(1570-67-8)

Safety Data

• Hazardous Substances Data: 1570-67-8(Hazardous Substances Data)

Usage

Usage

Commonly used as an antibacterial and antifungal agent in personal care products (e.g. soaps, toothpaste, cosmetics)

Effectiveness

Effective at killing a wide range of microorganisms and preventing bacterial and fungal growth

Health Concerns

Potential adverse effects on human health (e.g. contributing to antibiotic resistance, endocrine disruption)

Environmental Impact

Identified as an environmental pollutant

Restrictions

Limited use in some countries due to concerns about its impact on human health and the environment

Upstream product

• 1124-04-5 2-chloro-4,5-dimethylphenol 
• 95-65-8 3,4-Dimethylphenol 

Downstream Products

• 20012-39-9 2,4,6-trichloro-3,4-dimethylcyclohexa-2,5-dienone 

Relevant articles and documents

Primary Amines as Renin Inhibitors

The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYLONONENE DERIVATIVES

The invention relates to bicyclononene derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYCLIC FIVE-MEMBERED HETEROARYL DERIVATIVES AND THEIR USE AS RENIN INHIBITORS

The invention relates to novel five-membered heteroaryl derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions comprising one or more of those compounds and especially their use as inhibitors of renin.

Electrophilic Chlorination of 4-Methylphenols with Molecular Chlorine. Synthesis of Dimethoxy Aromatics by Methanolysis of 4-Chloro-4-methylcyclcohexa-2,5-dienones

The chlorination of p-cresol (1a), 2,4-dimethylphenol (1b), 3,4-dimethylphenol (1c), 2,4,5-trimethylphenol (1d), 2,4,6-trimethylphenol (1e) and the various possible mono- and dichloro derivatives of these phenols (3a-d, 6a and 6 c) with molecular chlorine was investigated in dichloromethane or dimethyl formamide solution.The 2,6-substituted p-cresol derivatives all give quantitative yields of 4-chloro-4-methylcyclohexa-2,5-dienones (5b, 5d, 7a, 7c and 2e), whereas the less substituted p-cresol derivatives give a 20-25percent yield of corresponding 4-chloro-4-methylcyclohexa-2,5-dienones (2a-d, 5a and 5c), the other products being chlorinated phenols.Treatment of 4-chloro-4-methylcyclohexa-2,5-dienones with at least one of the double bonds of the ring unsubstituted (2a-c and 4a) with methanol gave a quantitative yield of a 1,3-dimethoxybenzene derivative (9a-c and 10), whereas similar treatment of 4-chloro-2,4,5-trimethylcyclohexa-2,5-dienone (2d) gave 5-methoxy-2,3-dimethylbenzyl methyl ether (11).Treatment of the other 4-chlorodienones with methanol gave the corresponding 4-methoxydienones.Electrophilic chlorination of certain p-cresol derivatives followed by methanolysis hence is a facile although low-yield method for 3-methoxylation or selective side chain oxidation of these p-cresol derivatives.