1570097-49-2Relevant academic research and scientific papers
Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction
Li, Haoquan,He, Lin,Neumann, Helfried,Beller, Matthias,Wu, Xiao-Feng
supporting information, p. 1336 - 1343 (2014/03/21)
A cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides through a palladium-catalyzed carbonylation reaction has been developed. Various quinazolinones were produced in moderate to excellent yields. The reactions go through aminocarbonylation of aryl bromides-hydration of nitriles-cyclization sequence. Notably, all the products were isolated by recrystallization.
