1570105-01-9Relevant academic research and scientific papers
Highly enantioselective organocatalyzed vinylogous Michael-type reaction for the construction of trifluoromethylated all-carbon quaternary stereocenters
Chen, Qiao,Wang, Guoqiang,Jiang, Xianxing,Xu, Zhaoqing,Lin, Li,Wang, Rui
supporting information, p. 1394 - 1397 (2014/04/03)
The first example of a highly enantioselective vinylogous Michael-type reaction of β,β-disubstituted nitroalkenes is disclosed. A series of biologically important chiral oxindoles, featuring a trifluoromethylated all-carbon quaternary chiral center, were obtained in good yields with excellent enantioselectivities (up to >99% ee).
