157014-26-1Relevant academic research and scientific papers
Water-soluble propofol analogues with intravenous anaesthetic activity
Cooke, Andrew,Anderson, Alison,Buchanan, Kirsteen,Byford, Alan,Gemmell, David,Hamilton, Niall,McPhail, Petula,Miller, Susan,Sundaram, Hardy,Vijn, Peter
, p. 927 - 930 (2001)
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents.
Pharmaceutically active bicyclic-heterocyclic amines
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, (2008/06/13)
The pharmaceutically active bicyclic heterocyclic amines (XXX) STR1 where W1 is --N= or --CH=; W3 is --N= or --CH=; W5 is --N= or --CR5 -- with the proviso that W5 is --CR5 -- when both W1 and W3 are --N= which are useful as pharmaceuticals in treating mild and/or moderate to severe head injury, subarachnoid hemorrhage and subsequent ischemic stroke, asthma and reduction of mucous formation/secretion in the lung and other diseases and injuries.
