157047-97-7 Usage
Description
Benzomalvin B is a fungal metabolite, originally isolated from the Penicillium genus. It functions as an antagonist of neurokinin-1 (NK1) receptors, displaying the ability to inhibit the binding of substance P by 24% in vitro when applied at a concentration of 100 μg/ml.
Uses
Used in Pharmaceutical Applications:
Benzomalvin B is used as a neurokinin-1 (NK1) receptor antagonist for its potential role in treating conditions related to the neurokinin receptor system. By inhibiting the binding of substance P, it may contribute to the management of pain, inflammation, and other neurological disorders associated with the overstimulation of NK1 receptors.
Used in Research and Development:
In the field of scientific research, benzomalvin B serves as a valuable tool for studying the function and role of neurokinin-1 receptors. Its antagonistic properties allow researchers to investigate the underlying mechanisms of substance P binding and the subsequent cellular responses, which can lead to a better understanding of related diseases and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 157047-97-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,0,4 and 7 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 157047-97:
(8*1)+(7*5)+(6*7)+(5*0)+(4*4)+(3*7)+(2*9)+(1*7)=147
147 % 10 = 7
So 157047-97-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H17N3O2/c1-26-21(15-16-9-3-2-4-10-16)22-25-19-13-7-5-11-17(19)24(29)27(22)20-14-8-6-12-18(20)23(26)28/h2-15H,1H3/b21-15+
157047-97-7Relevant articles and documents
1H NMR Reassignment for Z/E-Benzomalvins B and Absolute Configuration of Benzomalvin C
Chao, Rong,Wu, Yan-Wei,Lu, Ling,Xu, Wei-Feng,Wang, Chang-Yun,Shao, Chang-Lun
, (2021)
Benzomalvins B, C, and E (1, 2, and 3) were simultaneously obtained from the marine fungus Aspergillus sp. isolated from the soft coral Sinularia sp., collected from South China Sea. Their structures were elucidated on the basis of NMR spectroscopic data
