157063-62-2

Basic information

• Product Name: phenoxy-acetic acid cyclohexylidenehydrazide
• CAS NO: 157063-62-2
• Molecular Weight: 246.309
• Mol File: 157063-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: phenoxy-acetic acid cyclohexylidenehydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: phenoxy-acetic acid cyclohexylidenehydrazide(157063-62-2)
• EPA Substance Registry System: phenoxy-acetic acid cyclohexylidenehydrazide(157063-62-2)

Safety Data

• Hazardous Substances Data: 157063-62-2(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 4664-55-5 phenoxyacetyl hydrazine 
• 2065-23-8 methyl 2-phenoxyacetate 

Relevant articles and documents

Synthesis and anti-coronavirus activity of a series of 1-thia-4-azaspiro[4.5]decan-3-one derivatives

A series of 1-thia-4-azaspiro[4.5]decan-3-ones bearing an amide group at C-4 and various substitutions at C-2 and C-8 were synthesized and evaluated against human coronavirus and influenza virus. Compounds 7m, 7n, 8k, 8l, 8m, 8n, and 8p were found to inhibit human coronavirus 229E replication. The most active compound was N-(2-methyl-8-tert-butyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)-3-phenylpropanamide (8n), with an EC50 value of 5.5 μM, comparable to the known coronavirus inhibitor, (Z)-N-[3-[4-(4-bromophenyl)-4-hydroxypiperidin-1-yl]-3-oxo-1-phenylprop-1-en-2-yl]benzamide (K22). Compound 8n and structural analogs were devoid of anti-influenza virus activity, although their scaffold is shared with a previously discovered class of H3 hemagglutinin-specific influenza virus fusion inhibitors. These findings point to the 1-thia-4-azaspiro[4.5]decan-3-one scaffold as a versatile chemical structure with high relevance for antiviral drug development.