1571190-65-2Relevant academic research and scientific papers
3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11β- hydroxysteroid dehydrogenase 1 inhibitor
Lee, Younho,Shin, Yong June,Ahn, Soon Kil
, p. 1421 - 1425 (2014/03/21)
Many adamantane derivatives have been demonstrated to function as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 3-Amino-N-adamantyl-3-methylbutanamide derivatives were optimized by structure-based drug design. Compound 8j exhibited a good in vitro and ex vivo inhibitory activity against both human and mouse 11β-HSD1.
