157141-16-7 Usage
Uses
Used in Pharmaceutical Industry:
(2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE is used as a pharmaceutical compound for its antagonistic activity against group II metabotropic glutamate receptors (mGluRs). This makes it a potential therapeutic agent for various neurological and psychiatric disorders, such as anxiety, depression, and chronic pain, where modulation of mGluRs is believed to play a role in their pathophysiology.
Used in Research Applications:
In the field of neuroscience research, (2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE serves as a valuable research tool. It is used to investigate the role of group II mGluRs in synaptic plasticity, learning, and memory processes. By blocking these receptors, researchers can gain insights into the underlying mechanisms of various neurological conditions and develop novel therapeutic strategies.
Used in Drug Development:
(2S,3S,4S)-2-METHYL-2-(CARBOXYCYCLOPROPYL)GLYCINE is also utilized in the development of new drugs targeting group II mGluRs. Its antagonistic properties make it a promising lead compound for the creation of more potent and selective medications with fewer side effects. This could lead to the development of innovative treatments for a range of neurological and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 157141-16-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,1,4 and 1 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157141-16:
(8*1)+(7*5)+(6*7)+(5*1)+(4*4)+(3*1)+(2*1)+(1*6)=117
117 % 10 = 7
So 157141-16-7 is a valid CAS Registry Number.
157141-16-7Relevant academic research and scientific papers
Stereospecific synthesis and absolute configuration of the (2S,3S,4S)-isomer of 2-methyl-2-(carboxycyclopropyl)glycine (MCCG)
Pajouhesh, Hassan,Curry, Kenneth,Pajouhesh, Hossein,Meresht, Mahmonir H.,Patrick, Brian
, p. 593 - 596 (2007/10/03)
The conformationally restricted metabotropic glutamate receptor antagonist (2S,3S,4S)-2-methyl-2-(carboxycyclopropyl)glycine 1 (MCCG) has been synthesized in a stereoselective manner (>99% ee) with the (2S,3S,4S) absolute configuration of this molecule be
EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS
-
, (2008/06/13)
The present invention provides compounds of formula STR1 in which R represents an organic group, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists o
Synthesis of (2S,1'S,2'S)-2-methyl-2-(carboxycyclopropyl)glycine and (S)-2-amino-2-methyl-4-phosphonobutyric acid from L-alanine
Ma, Dawei,Ma, Zhaochun,Jiang, Jiqing,Yang, Zhen,Zheng, Chongzhi
, p. 889 - 893 (2007/10/03)
The synthesis of two isotype-selective antagonists for metabotropic glutamate receptors, (2S,1'S,2'S)-2-methyl-2-(carboxycyclopropyl)glycine (S)-2-amino-2-methyl-4-phosphonobutyric acid from L-alanine is described.
