1571780-12-5Relevant articles and documents
Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel
Olsson, Roine I.,Jacobson, Ingemar,Iliefski, Tommy,Bostr?m, Jonas,Davidsson, ?jvind,Fjellstr?m, Ola,Bj?re, Annika,Olsson, Christina,Sundell, Johan,Gran, Ulrik,Gyll, Jonna,Malmberg, Jesper,Hidest?l, Olle,Emten?s, Hans,Svensson, Tor,Yuan, Zhong-Qing,Strandlund, Gert,?strand, Annika,Lindhardt, Emma,Linhardt, Gunilla,Forsstr?m, Elin,H?gberg, ?got,Persson, Frida,Andersson, Birgit,R?nnborg, Anna,L?fberg, Boel
, p. 1269 - 1273 (2014)
A series of lactam sulfonamides has been discovered and optimized as inhibitors of the Kv1.5 potassium ion channel for treatment of atrial fibrillation. In vitro structure-activity relationships from lead structure C to optimized structure 3y are described. Compound 3y was evaluated in a rabbit PD-model and was found to selectively prolong the atrial effective refractory period at submicromolar concentrations.
