15718-49-7

Basic information

• Product Name: GUANOSINE 2':3'-CYCLIC MONOPHOSPHATE SODIUM SALT
• Synonyms: GUANOSINE 2':3'-CYCLIC MONOPHOSPHATE SODIUM SALT;GUANOSINE-2',3'-CYCLIC MONOPHOSPHATE SODIUM SALT;guanosine 2':3'-cyclic monophosphate*sodium;Guanosine, cyclic 2',3'-(hydrogen phosphate), monosodium salt;guanosine 2',3'-cyclophosphate monosodium salt;Guanosine 2',3'-phosphatesodium salt
• CAS NO: 15718-49-7
• Molecular Formula: C₁₀H₁₁N₅O₇P*Na
• Molecular Weight: 367.19
• EINECS: 239-811-1
• Mol File: 15718-49-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 778.4°Cat760mmHg
• Flash Point: 424.5°C
• Appearance: /
• Density: 2.64g/cm³
• Storage Temp.: −20°C
• Solubility: H2O: soluble
• CAS DataBase Reference: GUANOSINE 2':3'-CYCLIC MONOPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: GUANOSINE 2':3'-CYCLIC MONOPHOSPHATE SODIUM SALT(15718-49-7)
• EPA Substance Registry System: GUANOSINE 2':3'-CYCLIC MONOPHOSPHATE SODIUM SALT(15718-49-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 15718-49-7(Hazardous Substances Data)

Usage

General Description

Guanosine 2':3'-cyclic monophosphate (cGMP) sodium salt is a cyclic nucleotide that functions as a second messenger in signal transduction pathways. It plays a crucial role in regulating various physiological processes such as smooth muscle relaxation, neurotransmission, platelet aggregation, and retinal phototransduction. cGMP acts by activating protein kinase G and modulating ion channels and phosphodiesterases. The sodium salt form of cGMP is commonly used in research and pharmaceutical applications as it is more stable and soluble in aqueous solutions, making it easier to handle and administer. It is also widely used in studies of cellular signaling and as a reference standard for cGMP measurements.

Upstream product

• 118-00-3 G 
• 6027-83-4 3'-guanosinemonophosphate disodium salt 

Relevant articles and documents

Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions

Prebiotic phosphorylation of (pre)biological substrates under aqueous conditions is a critical step in the origins of life. Previous investigations have had limited success and/or require unique environments that are incompatible with subsequent generation of the corresponding oligomers or higher-order structures. Here, we demonstrate that diamidophosphate (DAP) - a plausible prebiotic agent produced from trimetaphosphate - efficiently (amido)phosphorylates a wide variety of (pre)biological building blocks (nucleosides/tides, amino acids and lipid precursors) under aqueous (solution/paste) conditions, without the need for a condensing agent. Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed under the same phosphorylation reaction conditions. This plausible prebiotic phosphorylation process under similar reaction conditions could enable the systems chemistry of the three classes of (pre)biologically relevant molecules and their oligomers, in a single-pot aqueous environment.