1571899-58-5Relevant academic research and scientific papers
Copper(I)-Catalyzed N-Carboxamidation of Indoles with Isocyanates: Facile and General Method for the Synthesis of Indole-1-carboxamides
Chen, Jinyang,Hu, Li,Wang, Haiying,Liu, Lingrong,Yuan, Binfang
, p. 3949 - 3954 (2019)
A facile and general method for the synthesis of indole-1-carboxamides was developed via copper(I)-catalyzed N-carboxamidation of indoles with isocyanates under mild reaction conditions. This process is scalable and tolerates a wide spectrum of indoles and isocyanates to deliver corresponding products in good to excellent yields, providing a viable synthetic approach to indole-1-carboxamides, which can be used for the treatment of inflammatory diseases and diabetes.
Rh-catalyzed oxidative C-C bond formation and C-N bond cleavage: Direct access to C2-olefinated free (NH)-indoles and pyrroles
Sharma, Satyasheel,Han, Sangil,Kim, Mirim,Mishra, Neeraj Kumar,Park, Jihye,Shin, Youngmi,Ha, Jimin,Kwak, Jong Hwan,Jung, Young Hoon,Kim, In Su
supporting information, p. 1703 - 1706 (2014/03/21)
The rhodium-catalyzed oxidative C2-olefination of indoles and pyrroles containing N-arylcarboxamide directing groups with a range of alkenes and subsequent cleavage of directing groups is described. This method provides direct and efficient access to C2-functionalized free (NH)-heterocycles.
