1571925-65-9Relevant academic research and scientific papers
NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: A high-efficiency synthesis of spirocyclic oxindole-dihydropyranones
Liu, Rui,Yu, Chenxia,Xiao, Zhaoxin,Li, Tuanjie,Wang, Xiangshan,Xie, Yuanwei,Yao, Changsheng
, p. 1885 - 1891 (2014)
This manuscript discloses an efficient construction of the spirocyclic oxindole-dihydropyranone scaffold via the N-heterocyclic carbene (NHC)-catalyzed oxidative γ-functionalization of α,β-unsaturated aldehydes bearing γ-H with isatin derivatives. The ready availability of the starting materials, easy work-up, mild reaction conditions and the potential utilization value of the products make this strategy attractive.
