157198-80-6Relevant articles and documents
2-(benzimidazol-1-yl)-acetamide bisaryl derivatives
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Page/Page column 5, (2008/06/13)
The invention relates to 2-(benzimidazol-1-yl)-acetamide bisaryl derivative having the general Formula I wherein n is 0 or 1; Ar1 represents a diradical derived from a 5- or-6-membered aromatic ring, optionally comprising 1-3 heteroatoms selected from N, O and S, said ring being optionally substituted with (C1-4)alkyl, (C1-4)alkyloxy, halogen, CF3 or cyano; Ar2 represents a 6-membered aryl ring, optionally comprising 1-3 nitrogen atoms, said ring being optionally substituted with 1-3 substituents selected from (C1-4)alkyl (optionally substituted with 1 or more halogens), (C1-4)alkyloxy (optionally substituted with 1 or more halogens), di(C1-4)alkylamino, halogen, CF3 or cyano; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same and to the use of said 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives in the treatment of TRPV1 mediated disorders.
Homolytic substitution and carbenoidic reactions in the preparation of benzimidazole derivatives of pharmaceutical interest: Synthesis and properties of (2-cycloalkyl-1-benzimidazolyl)-N,N-diethylacetamides
Pellicciari,Fringuelli,Natalini,Brucato,Contessa
, p. 393 - 399 (2007/10/02)
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