1571988-86-7Relevant articles and documents
Synthesis and antiviral evaluation of novel 2′,2′-difluoro 5′-norcarbocyclic phosphonic acid nucleosides as antiviral agents
Shen, Guang Huan,Hong, Joon Hee
, p. 1 - 17 (2014)
A very efficient synthetic route to novel 2′,2′-difluoro 5′-norcarbocyclic phosphonic acid nucleosides from but-3-en-1-ol 5 is described. The discovery of 2′-fluorinated furanose nucleoside 1 as a potent anti-HIV-1 agent has led to the synthesis and biological evaluation of 2′-modified 5′-norversions of the carbocyclic phosphonate nucleosides. The synthesized nucleoside analogues 18, 19, 23a, 23b, and 24 were tested for anti-HIV activity as well as cytotoxicity. Adenine analogue 19 shows significant anti-HIV-1 activity (EC50 = 13 μM).
NOVEL COMPOUNDS
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Paragraph 0720-0722, (2015/09/22)
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein L, X, Ra, Rb, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
