1572-06-1

Basic information

• Product Name: 2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE
• Synonyms: ASISCHEM D50991;AKOS BB-7922;2-(4-METHYLPHENYL)-1H-BENZIMIDAZOL-5-AMINE;2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE
• CAS NO: 1572-06-1
• Molecular Formula: C₁₄H₁₃N₃
• Molecular Weight: 223.27
• Mol File: 1572-06-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 475.9±47.0 °C(Predicted)
• Appearance: /
• Density: 1.247±0.06 g/cm3(Predicted)
• PKA: 10.90±0.10(Predicted)
• CAS DataBase Reference: 2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE(1572-06-1)
• EPA Substance Registry System: 2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE(1572-06-1)

Safety Data

• Hazardous Substances Data: 1572-06-1(Hazardous Substances Data)

Usage

General Description

2-P-Tolyl-1H-benzoimidazol-5-ylamine is a chemical compound with the molecular formula C15H13N3. It is also known by the chemical name N-(2-methylphenyl)-2-phenylbenzo[d]imidazole-5-amine. 2-P-TOLYL-1H-BENZOIMIDAZOL-5-YLAMINE belongs to the class of organic compounds known as anilines, which are a type of aromatic amine derivative. It is commonly used in research and industrial applications as a building block or intermediate for the synthesis of pharmaceuticals and other organic compounds. Due to its unique structure, it exhibits various biological activities and has the potential for use in pharmaceutical development and as a research tool.

Upstream product

• 1571-90-0 2-(4-methylphenyl)-6-nitro-1H-benzo[d]imidazole 
• 104-87-0 4-methyl-benzaldehyde 
• 99-56-9 4-Nitrophenylene-1,2-diamine 
• 99-94-5 p-Toluic acid 
• 1571-90-0 2-(4-methyl-phenyl)-5-nitro-1H-benzimidazole 

Downstream Products

• 1329517-00-1 2-chloro-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)acetamide 
• 1329517-01-2 3-chloro-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)propanamide 
• 1329517-04-5 2-(4-ethylpiperazin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)acetamide 
• 1329517-07-8 2-(4-methylpiperazin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)acetamide 
• 1329517-09-0 2-morpholino-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)acetamide 
• 1329517-10-3 2-(piperidin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)acetamide 
• 1329517-13-6 3-(4-ethylpiperazin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)propanamide 
• 1329517-16-9 3-(4-methylpiperazin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)propanamide 
• 1329517-18-1 3-(piperidin-1-yl)-N-(2-p-tolyl-1H-benzo[d]imidazol-5-yl)propanamide 
• 1593834-46-8 N-(2-p-tolyl-1H-benzo[d]imidazol-6-yl)quinolin-4-amine 

Relevant articles and documents

Design, synthesis and in vitro evaluation of 6-amide-2-aryl benzoxazole/benzimidazole derivatives against tumor cells by inhibiting VEGFR-2 kinase

Herein, we have carried out a structural optimization campaign to discover the novel anti-tumor agents with our previously screened YQY-26 as the hit compound. A library of thirty-seven 6-amide-2-aryl benzoxazole/benzimidazole derivatives has been designe

Discovery of quinazolin-4-amines bearing benzimidazole fragments as dual inhibitors of c-Met and VEGFR-2

Both c-Met and VEGFR-2 are important targets for the treatment of cancers. In this study, a series of N-(2-phenyl-1H-benzo[d]imidazol-5-yl)quinazolin-4- amine derivatives were designed and identified as dual c-Met and VEGFR-2 inhibitors. Among these compounds bearing quinazoline and benzimidazole fragments, compound 7j exhibited the most potent inhibitory activity against c-Met and VEGFR-2 with IC50 of 0.05 μM and 0.02 μM, respectively. It also showed the highest anticancer activity against the tested cancer cell lines with IC50 of 1.5 μM against MCF-7 and 8.7 μM against Hep-G2. Docking simulation supported the initial pharmacophoric hypothesis and suggested a common mode of interaction at the ATP-binding site of c-Met and VEGFR-2, which demonstrates that compound 7j is a potential agent for cancer therapy deserving further researching.