15721-22-9

Basic information

• Product Name: 2,2-Dimethylvaleroyl chloride
• Synonyms: NEO-HEPTANOYL CHLORIDE;NHCL;2,2-DIMETHYLVALEROYL CHLORIDE;2,2-Dimethylpentanoyl chloride
• CAS NO: 15721-22-9
• Molecular Formula: C₇H₁₃ClO
• Molecular Weight: 148.63
• Mol File: 15721-22-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 83 at 77 mm Hg
• Flash Point: 44.7 °C
• Appearance: Clear to yellowish liquid
• Density: 0.973 g/cm³
• Vapor Pressure: 3.11mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 2,2-Dimethylvaleroyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethylvaleroyl chloride(15721-22-9)
• EPA Substance Registry System: 2,2-Dimethylvaleroyl chloride(15721-22-9)

Safety Data

• Hazardous Substances Data: 15721-22-9(Hazardous Substances Data)

Usage

General Description

2,2-Dimethylvaleroyl chloride is a chemical compound with the molecular formula C7H13ClO. It is a colorless and volatile liquid with a pungent odor. 2,2-Dimethylvaleroyl chloride is commonly used as a reagent in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. 2,2-Dimethylvaleroyl chloride is a versatile building block in the synthesis of various compounds, including esters, amides, and ketones. It is known for its high reactivity with nucleophiles, making it useful in a wide range of chemical reactions. However, it should be handled with care due to its potentially hazardous properties, including its corrosive nature and its ability to cause skin and eye irritation.

InChI:InChI=1/C7H13ClO/c1-4-5-7(2,3)6(8)9/h4-5H2,1-3H3

Upstream product

• 1185-39-3 2,2-dimethyl-n-valeric acid 

Downstream Products

• 804451-41-0 2,2-dimethyl-pentanoic acid N'-(2-hydroxy-1-methyl-2-phenyl-ethyl)-N'-methyl-hydrazide 
• 59518-03-5 2,2-Dimethyl-pentanoic acid [3-(2,2-dimethyl-pentanoylamino)-2-methyl-phenyl]-amide 
• 6079-53-4 2,2-Dimethyl-pentanoic acid (3-chloro-4-nitro-phenyl)-amide 
• 10023-87-7 N-(2,2-Dimethyl-valeryl)-4-nitro-3-trifluormethyl-anilin 
• 25228-48-2 2,2-Dimethyl-pentanoic acid [3-(2,2-dimethyl-propionylamino)-phenyl]-amide 
• 57540-43-9 2,2-Dimethyl-pentanoic acid 4-(2-tert-butylamino-acetyl)-2-hydroxy-phenyl ester 
• 25218-50-2 2,2-Dimethyl-pentanoic acid (3-phenylacetylamino-phenyl)-amide 
• 25228-24-4 2,2-Dimethyl-pentanoic acid [3-(3-isopropyl-ureido)-phenyl]-amide 
• 25228-23-3 2,2-Dimethyl-pentanoic acid [3-(3-propyl-ureido)-phenyl]-amide 
• 25304-25-0 2,2-Dimethyl-pentanoic acid [3-(3-allyl-ureido)-phenyl]-amide 
• 25228-25-5 2,2-Dimethyl-pentanoic acid [3-(3-butyl-ureido)-phenyl]-amide 
• 25228-26-6 2,2-Dimethyl-pentanoic acid [3-(3-cyclohexyl-ureido)-phenyl]-amide 
• 25228-57-3 2,2-Dimethyl-pentanoic acid [3-(3,3-dimethyl-butyrylamino)-phenyl]-amide 
• 25218-67-1 2,2-Dimethyl-pentanoic acid [3-(4,4-dimethyl-pentanoylamino)-phenyl]-amide 

Relevant articles and documents

LONG-ACTING CONTRACEPTIVE AGENTS: ESTER OF NORETHISTERONE WITH α- AND/OR β-CHAIN BRANCHING

The synthesis of eighteen esters of norethisterone (17α-ethynyl-17β-hydroxyestr-4-en-3-one) is described.These all possess some form of α- and/or β-substitution in the ester side-chain.The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds.A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.

Pd/Cu-Catalyzed Cascade C(sp3)-H Arylation and Intramolecular C-N Coupling: A One-Pot Synthesis of 3,4-2 H-Quinolinone Skeletons

In this letter, we successfully explored a cascade Pd/Cu-catalyzed intermolecular C(sp3)-H arylation of amides and intramolecular C-N coupling reaction. This method provides a one-pot strategy to synthesize 3,4-2H-quinolinone with good regioselectivity of C-H arylation and C-N coupling from C-I and C-X bonds from readily available starting materials.

Copper(II)-mediated intermolecular amination of inert C(sp3)[sbnd]H bonds with simple alkylamines to construct α,α-disubstituted β-amino acid derivatives

Disclosed herein is a copper(II)-mediated chelation-assisted intermolecular amination of inert C(sp3)[sbnd]H bonds using simple alkylamines as the amino source. A straightforward and step-economic alternative to α,α-disubstituted β-amino acid derivatives is provided consequently. This reaction features good functional group tolerance and relatively broad substrate scope. Furthermore, a coupling product between morpholine and radical inhibitor 2,6-di-tert-butyl-p-cresol (BHT) was isolated, indicating that a single electron transfer (SET) process might be involved in this transformation.

Nickel-Catalyzed oxidative coupling of unactivated C(sp3)-H bonds in aliphatic amides with terminal alkynes

In this work, we demonstrated Ni-catalyzed oxidative coupling of unactivated C(sp3)-H bonds with terminal alkynes for construction of C(sp3)-C(sp) bonds to synthesize alkyl-substituted internal alkynes. Different amides exhibited good compatibility. Preliminary mechanistic studies were conducted to account for this alkynylation.