1572178-40-5

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 1572178-39-2 (6-bromo-1-(phenylsulfonyl)-1H-indol-2-yl)methanol 
• 679794-03-7 1‐(benzenesulfonyl)‐6‐bromo‐1H‐indole 

Downstream Products

• 1572178-41-6 C₃₃H₂₆BrNO₂PS⁽¹⁺⁾*Br^(1-) 
• 1572178-43-8 (E)-6-bromo-2-(2-(5-bromo-1-(phenylsulfonyl)-1H-indol-2-yl)vinyl)-1-(phenulsulfonyl)-1H-indole 

Relevant academic research and scientific papers

ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR

The present invention relates to compounds of formula (I) wherein G1 to G8 are as defined herein. The compounds are PK inhibitors and as such represent a new approach to treating pathogenic infections, including multidrug resistant pathogens. Disclosed herein are the compounds of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and their use in the treatment of antimicrobial infection. (Formula (1))

ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS

Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial agents in therapeutic and/or non- therapeutic contexts.

Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections

A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which