1572178-47-2Relevant articles and documents
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections
Kumar, Nag S.,Dullaghan, Edie M.,Finlay, B. Brett,Gong, Huansheng,Reiner, Neil E.,Jon Paul Selvam,Thorson, Lisa M.,Campbell, Sara,Vitko, Nicholas,Richardson, Anthony R.,Zoraghi, Roya,Young, Robert N.
, p. 1708 - 1725 (2014/03/21)
A novel series of bis-indoles derived from naturally occurring marine alkaloid 4 were synthesized and evaluated as inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK). PK is not only critical for bacterial survival which