1572246-83-3Relevant articles and documents
Access to enantiopure 4-substituted 1,5-aminoalcohols from phenylglycinol-derived δ-lactams: Synthesis of Haliclona alkaloids
Amat, Mercedes,Guignard, Guillaume,Llor, Nuria,Bosch, Joan
, p. 2792 - 2802 (2014/04/17)
LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolopiperidone lactams leads to enantiopure 4-substituted-5-aminopentanols, which are used as starting building blocks in the synthesis of the Haliclona alkaloids haliclorensin C, haliclorensin, and halitulin (formal). The starting lactams are easily accessible by a cyclocondensation reaction of (R)-phenylglycinol with racemic γ-subtituted δ-oxoesters, in a process that involves a dynamic kinetic resolution.