1572247-75-6

Upstream product

• 344332-43-0 C₁₀H₁₂FNO₃ 
• 459-57-4 4-fluorobenzaldehyde 
• 437717-49-2 (E)-2-(4-fluorophenyl)-1-ethyl-1-nitroethylene 
• 1434076-19-3 2-Ethyl-3-(4-fluorophenyl)-2-nitrooxirane 
• 95-54-5 1,2-diamino-benzene 

Relevant academic research and scientific papers

Nitroepoxides as versatile precursors to 1,4-diamino heterocycles

Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.