157239-55-9Relevant academic research and scientific papers
KINETIC RESOLUTION OF RACEMIC GRIGNARD REAGENTS BY NICKEL-CATALYZED ASYMMETRIC GRIGNARD CROSS-COUPLING
Hayashi, Tamio,Kanehira, Koichi,Hioki, Tsuyoshi,Kumada, Makoto
, p. 137 - 140 (2007/10/02)
Racemic Grignard reagents, 2-phenylpropylmagnesium chloride and 2-norbornylmagnesium chloride were kinetically resolved by asymmetric cross-coupling with vinyl bromides in the presence of chiral phosphine-nickel catalysts to give optically active coupling products (ca. 37percent ee) and carboxylic acids after carbonation with carbon dioxide.
