1572439-01-0Relevant academic research and scientific papers
Preparation, biological & cheminformatics-based assessment of N2,N4-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials
Toviwek, Borvornwat,Phuangsawai, Oraphan,Konsue, Adchatawut,Hannongbua, Supa,Riley, Jennifer,Mutter, Nicole,Anderson, Mark,Webster, Lauren,Hallyburton, Irene,Read, Kevin D,Gleeson, M. Paul
, (2021/09/04)
Twenty eight new N2,N4-diphenylpyrimidine-2,4-diamines have been prepared in order to expand our understanding of the anti-malarial SAR of the scaffold. The aim of the study was to make structural modifications to improve the overall
Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents
Jia, Yuping,Zhang, Jian,Feng, Jinhong,Xu, Fuming,Pan, Huili,Xu, Wenfang
, p. 306 - 316 (2014/03/21)
A novel series of pazopanib derivatives were designed, synthesized, and evaluated for their inhibitory activity against a series of kinases including VEGFR-2, EGFR, AKT1, ALK1, and ABL1. The anti-angiogenic activities ex vivo of some compounds were also investigated. Compounds P2d and P2e demonstrated outstanding inhibitory activity against VEGFR-2 and ABL1 and higher anti-angiogenic activity compared with Pazopanib, the reference standard. These two compounds (P2d and P2e) could be used as novel lead compounds for further development of anticancer agents.
