15725-23-2

Basic information

• Product Name: Butanoic acid, 2-[(3-chlorophenyl)methylene]-3-oxo-, ethyl ester
• CAS NO: 15725-23-2
• Molecular Formula: C13H13ClO3
• Molecular Weight: 252.697
• Mol File: 15725-23-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(3-chlorophenyl)methylene]-3-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(3-chlorophenyl)methylene]-3-oxo-, ethyl ester(15725-23-2)
• EPA Substance Registry System: Butanoic acid, 2-[(3-chlorophenyl)methylene]-3-oxo-, ethyl ester(15725-23-2)

Safety Data

• Hazardous Substances Data: 15725-23-2(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 541-50-4 2-acetoacetic acid 
• 587-04-2 m-Chlorobenzaldehyde 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 404569-92-2 4-(3-chlorophenyl)-6-methyl-2-(methylthio)-1,4-dihydropyrimidine-5-carboxylic acid ethylester 
• 872682-62-7 ethyl 4-(3-chlorophenyl)-1-ethyl-6-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate 
• 108932-37-2 1,4-dihydro-6-methyl-4-(3-chlorophenyl)-2-[[(4-methoxyphenyl)methyl]thio]-5-pyrimidinecarboxylic acid, ethyl ester 
• 71145-05-6 4-(3-Chlorophenyl)-1,4-dihydro-2,6-dimethyl-3-nitro-pyridine-5-carboxylic acid ethyl ester 
• 114858-39-8 ethyl 6-chloro-2-methylquinoline-3-carboxylate 
• 909379-04-0 6-[(3-chlorophenyl)methyl]-5-methyl-4H-[1,2,4]triazolo[5,1-b]pyrimidin-7-one 
• 30292-75-2 ethyl 2-[(3-chlorophenyl)methyl]-3-oxobutanoate 
• 50620-86-5 6-methyl-4-(3-chlorophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 50620-71-8 7-(3-chloro-phenyl)-5-methyl-1,2,3,7-tetrahydro-imidazo[1,2-a]pyridine-6,8-dicarboxylic acid diethyl ester 
• 52508-58-4 2-dimethylamino-6-methyl-4-(3-chlorophenyl)-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester 
• 103293-62-5 ethyl 4-(3-chlorophenyl)-6-methyl-2-phenylpyrimidine-5-carboxylate 
• 136814-26-1 ethyl 7-(3-chlorophenyl)-5,8a-dimethyl-8-methoxycarbonyl-2,3,8,8a-tetrahydro-7H-oxazolo<3,2-a>pyridin-6-carboxylate 
• 143996-70-7 4-(3-Chloro-phenyl)-6-methyl-2-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 50620-13-8 7-(3-chloro-phenyl)-5-methyl-2,3-dihydro-7H-oxazolo[3,2-a]pyridine-6,8-dicarboxylic acid diethyl ester 

Relevant articles and documents

Alkoxy base-mediated selective synthesis and new rearrangements of 1,2,4-triazolodipyrimidinones

A versatile approach for the synthesis of [1,2,4]triazolodipyrimidinones with various annulations of the triazole and pyrimidine rings was developed. The isomeric triazolodipyrimidinones were obtained by the stepwise condensation of partially hydrogenated

Enzyme catalytic promiscuity: The papain-catalyzed Knoevenagel reaction

Papain as a sustainable and inexpensive biocatalyst was used for the first time to catalyze the Knoevenagel reactions in DMSO/water. A wide range of aromatic, hetero-aromatic and α,β-unsaturated aldehydes could react with less active methylene compounds acetylacetone and ethyl acetoacetate. The products were obtained in moderate to excellent yields with Z/E selectivities of up to 100:0. This case of biocatalytic promiscuity not only widens the application of papain to new chemical transformations, but also could be developed into a potentially valuable method for organic synthesis.

A simple method for the preparation of functionalized trisubstituted alkenes and α,β,γ,δ-unsaturated carbonyl compounds by using natural amino acid l-tryptophan

Primary natural amino acid l-tryptophan was used, for the first time, as a catalyst in Knoevenagel condensations of aliphatic, aromatic, hetero-aromatic and α,β-unsaturated aldehydes with less reactive acetylacetone and ethyl acetoacetate. The reactions were carried out at room temperature and gave good yields. It is a convenient entry for preparation of functionalized trisubstituted alkenes and α,β,γ,δ-unsaturated carbonyl compounds.