15725-53-8

Upstream product

• 619-66-9 4-Carboxybenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 333963-69-2 4-(6-amino-3,5-dicyano-2-thioxo-1,2-dihydro-pyridin-4-yl)-benzoic acid 
• 1270162-35-0 C₁₆H₁₂N₂O₂ 

Relevant academic research and scientific papers

A novel eco-friendly process for the synthesis of 2- chlorobenzylidenemalononitrile and its analogues using water as a solvent

A simple and novel eco-friendly process for the synthesis of 2-chlorobenzylidene malononitrile (CS) and their analogues in water using 1-methyl imidazole (catalyst) has been developed. The reaction conditions for the preparation of CS are optimized for la

Synthesis of structurally enhanced magnetite cored poly(propyleneimine) dendrimer nanohybrid material and evaluation of its functionality in sustainable catalysis of condensation reactions

The conventional method of dendrimer synthesis especially poly(propyleneimine) dendrimer (PPI) involves complicated reaction workup and tedious separation strategies. Since it has greater number of nitrogen atom in their structure, its applications are in

A Zn based metal organic framework as a heterogeneous catalyst for C-C bond formation reactions

Herein, we report the synthesis and application of a Zn-Bp-BTC MOF (Bp-4,4′-bipyridine; BTC-1,3,5-benzene tricarboxylic acid; MOF-metal organic framework) as a heterogeneous catalyst for mediating organic reactions. Initially, conditions were optimized for the Knoevenagel condensation reaction using Zn-Bp-BTC as a heterogeneous catalyst by varying the solvent, temperature and catalyst loading. Although the reaction proceeded at room temperature using methanol as the solvent, 60 °C offered the best yield in a shorter duration. Under optimized reaction conditions, a wide range of α,β-unsaturated dicyano compounds were prepared from the corresponding carbonyl precursor and malononitrile, the active methylene counterpart. Systematic investigation was also carried out to assess the role of the ligand and metal salt in the Knoevenagel condensation reaction. It was found that the Zn-Bp-BTC MOF catalyzed the reaction efficiently in comparison to its analogue Zn-BTC MOF and precursor Zn(NO3)2·6H2O. Finally, catalytic recycling and stability studies showed that the catalyst is able to mediate the reaction for up to five consecutive cycles without undergoing any significant chemical or morphological changes. Further, the catalyst was tested for its efficacy in a multi-component reaction (MCR). A MCR with the Zn-Bp-BTC MOF as the catalyst afforded good yields and there was no reaction in the absence of the catalyst. Similarly, the catalyst was tested for its efficiency in benzimidazole synthesis.

An Efficient and Reusable Multifunctional Composite Magnetic Nanocatalyst for Knoevenagel Condensation

A range of multifunctional magnetic metal-organic framework nanomaterials consisting of various mass ratios of the metal-organic framework MIL-53(Fe) and magnetic SiO 2 @NiFe 2 O 4 nanoparticles were designed, prepared, ch

FIBROTIC TREATMENT

The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group inclu

Microporous polyurethane material for size selective heterogeneous catalysis of the Knoevenagel reaction

The first polyurethane material which is microporous (BET surface area of 312 m2 g-1) is prepared by solvothermal synthesis and acts as highly efficient and recyclable heterogeneous catalyst in the Knoevenagel condensation showing si

4H-PYRAN COMPOUNDS AS INSULIN-REGULATED AMINOPEPTIDASE (IRAP) INHIBITORS

The present disclosure relates to 4H-pyran compounds of formula (I) and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosu

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes,

Highly efficient mesoporous base catalyzed Knoevenagel condensation of different aromatic aldehydes with malononitrile and subsequent noncatalytic Diels-Alder reactions

Knoevenagel condensation and [4 + 2] cycloaddition reactions are very important class of reactions in synthetic organic chemistry. We have prepared amino-functionalized mesoporous silica through co-condensation of 3-aminopropyltriethoxy-silane (APTES) alo

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: Parallel synthesis, bioactivity, and in vitro pharmacokinetics

2-Aminopyridine-3,5-dicarbonitrile compounds were previously identified as mimetics of dominant-negative prion protein mutants and inhibit prion replication in cultured cells. Here, we report findings from a comprehensive structure-activity relationship study of the 6-aminopyridine-3,5-dicarbonitrile scaffold. We identify compounds with significantly improved bioactivity (approximately 40-fold) against replication of the infectious prion isoform (PrPSc) and suitable pharmacokinetic profiles to warrant evaluation in animal models of prion disease.