1572518-81-0

Basic information

• Product Name: (R)-P,P-diphenyl-N-(1-phenylbut-3-yn-1-yl)phosphinic amide
• CAS NO: 1572518-81-0
• Molecular Weight: 345.381
• Mol File: 1572518-81-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-P,P-diphenyl-N-(1-phenylbut-3-yn-1-yl)phosphinic amide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-P,P-diphenyl-N-(1-phenylbut-3-yn-1-yl)phosphinic amide(1572518-81-0)
• EPA Substance Registry System: (R)-P,P-diphenyl-N-(1-phenylbut-3-yn-1-yl)phosphinic amide(1572518-81-0)

Safety Data

• Hazardous Substances Data: 1572518-81-0(Hazardous Substances Data)

Upstream product

• 865350-17-0 4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane 
• 98837-46-8 P,P-diphenyl-N-(phenylmethylene)phosphinic amide 
• 1337935-39-3 4,4,5,5-tetramethyl-2-(prop-2-yn-1-yl)-1,3,2-dioxaborolane 

Relevant articles and documents

An efficient, practical, and enantioselective method for synthesis of homoallenylamides catalyzed by an aminoalcohol-derived, boron-based catalyst

A practical catalytic method for enantioselective addition of an allene unit to aldimines is disclosed. Transformations are promoted by an in-situ-generated B-based catalyst that is derived from a simple, robust, and readily accessible (in multigram quantities) chiral aminoalcohol. A range of aryl-, heteroaryl-, and alkyl-substituted homoallenylamides can be obtained in 66-91% yield and 84:16 to >99:1 enantiomeric ratio through reactions performed at ambient temperature and in the presence of 0.1-3.0 mol% of the chiral catalyst and a commercially available allenylboron reagent. The catalytic protocol does not require strict anhydrous conditions, can be performed on gram scale, and promotes highly selective addition of an allenyl unit (vs a propargyl group). The utility of the approach is demonstrated through development of succinct approaches to syntheses of anisomycin and epi-cytoxazone.