157255-48-6Relevant academic research and scientific papers
Synthesis of enantiomeric β-amino ketones via 1,3-dipolar cycloaddition and chromatographic resolution
Louis, Chantal,Mill, Sibel,Mancuso, Vincent,Hootele, Claude
, p. 1347 - 1350 (2007/10/02)
The cycloaddition reactions of 3,4,5,6-tetrahydropyridine 1-oxide 1 with the homochiral alkynyl sulfoxides 6a-e proceed in high yield to afford, with low asymmetric induction, mixtures of diastereomeric isoxazolines that are readily separated by column chromatography.The resolved isoxazolines can be subsequently converted, by hydrogenolysis, to enantiomeric β-amino ketones.
