15728-26-4Relevant articles and documents
An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines
Shen, Dandan,Xu, Yanjie,He, Dong,Han, Jing,Chen, Jie,Deng, Hongmei,Shao, Min,Zhang, Hui,Cao, Weiguo
, p. 524 - 532 (2016)
A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mil
Diastereoselective construction of a functionalized dihydro-pyridazine-based spirooxindole scaffold: Via C-3 umpolung of isatin N, N ′-cyclic azomethine imine
Moghaddam, F. Matloubi,Eslami,Siahpoosh,Hoda
, p. 10318 - 10323 (2019)
Herein, functionalized spiro[indoline-3,5′-pyrazolo[1,2-a]pyridazine]-7′-carbonitrile containing two contiguous chiral stereocenters was efficiently synthesized in a satisfactory yield (up to 91% yield) and with excellent diastereoselectivity. We have rea
Amine-functionalized hollow mesoporous nano-bowl with bulky acid-imprinted free space around base sites and DMF-annealed mesoporous channels as an efficient solid base catalyst
Li, Shan,Ma, Xuebing,Wei, Shuai,Zhang, Jianing,Zhang, Li
, (2020)
Tailoring free spaces around catalytic sites and constructing inter-connected channels between them are highly attractive for achieving easy accessibility of reactants to catalytic sites. In this study, a strategy for constructing free space around base s
Enantioselective Michael addition to vinyl phosphonatesviahydrogen bond-enhanced halogen bond catalysis
Erkman, Kristin,J?rving, Ivar,Kaasik, Mikk,Kanger, T?nis,Mart?nova, Jevgenija,Metsala, Andrus
, p. 7561 - 7568 (2021)
An asymmetric Michael addition of malononitrile to vinyl phosphonates was accomplished by hydrogen bond-enhanced bifunctional halogen bond (XB) catalysis. NMR titration experiments were used to demonstrate that halogen bonding, with the support of hydrogen-bonding, played a key role in the activation of the Michael acceptors through the phosphonate group. This is the first example of the use of XBs for the activation of organophosphorus compounds in synthesis. In addition, the iodo-perfluorophenyl group proved to be a better directing unit than different iodo- and nitro-substituted phenyl groups. The developed approach afforded products with up to excellent yields and diastereoselectivities and up to good enantioselectivities.
Stereoselective one-pot synthesis of polycyanosubstituted piperidines
Vereshchagin, Anatoly N.,Karpenko, Kirill A.,Elinson, Michail N.,Gorbunov, Sergey V.,Gordeeva, Alexandra M.,Proshin, Pavel I.,Goloveshkin, Alexander S.,Egorov, Mikhail P.
, p. 1979 - 1989 (2018)
Abstract: An effective and facile multicomponent method for the synthesis of polysubstituted piperidines is described. The Michael–Mannich type cascade of benzylidenemalononitriles with aromatic aldehydes and ammonium acetate or aqueous ammonia provides c
Hydroquinone and benzoquinone-catalyzed aqueous Knoevenagel condensation
Koyama, Kaho,Kuwata, Marina,Sajiki, Hironao,Sawama, Yoshinari,Takakura, Ryoya,Yamada, Tsuyoshi
, p. 6594 - 6597 (2020)
A Knoevenagel condensation of various aldehydes with malononitrile effectively proceeded in the presence of hydroquinone/benzoquinone mixed catalysts at room temperature in H2O. Furthermore, γ-deuterium-labeled α,β-unsaturated nitrile derivatives were als
Amino-functionalized Zr(IV) metal-organic framework as bifunctional acid-base catalyst for Knoevenagel condensation
Yang, Yang,Yao, Hong-Fei,Xi, Fu-Gui,Gao, En-Qing
, p. 198 - 205 (2014)
The amino-functionalized metal-organic framework of Zr(IV) with 2-aminoterephthalate, UiO-66-NH2, was studied as a solid catalyst for Knoevenagel condensation. The material can efficiently catalyze the condensation reaction of benzaldehyde with
Synthesis, molecular docking, and in silico ADME prediction of some fused pyrazolo[1,5-a]pyrimidine and pyrazole derivatives as potential antimicrobial agents
Hassan, Ashraf S.,Morsy, Nesrin M.,Awad, Hassan M.,Ragab, Ahmed
, p. 521 - 545 (2022)
Twenty compounds of pyrazolo[1,5-a]pyrimidines 14a–j and pyrazole derivatives as Schiff bases 16a–j have been synthesized by the reaction of 5-amino-pyrazole derivatives 9a, b with 2-(arylidene)malononitriles 10a–e or various aldehydes 15a–e, respectively
Biguanide-functionalized hierarchical porous covalent organic frameworks for efficient catalysis of condensation reactions
Feng, Huiru,Gong, Kai,Li, Cunhao,Li, Haoran,Wang, Yunyun,Zhang, Daquan,Zhang, Huimin
, (2021/07/21)
Covalent organic frameworks (COFs) can be rationally designed with desired physicochemical properties for a far-ranging application in catalytic systems. Herein, a biguanide-functionalized covalent organic framework was designed and prepared via N-alkylat
Kinetically Controllable Pd-Catalyzed Decarboxylation Enabled [5 + 2] and [3 + 2] Cycloaddition toward Carbocycles Featuring Quaternary Carbons
Yan, Biwei,Zuo, Linhong,Chang, Xiaowei,Liu, Teng,Cui, Manying,Liu, Yang,Sun, Haiyu,Chen, Weipeng,Guo, Wusheng
supporting information, p. 351 - 357 (2021/01/26)
A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis.
