15728-34-4

Usage

Uses

Used in Pharmaceutical Industry:
EHPN is used as an antimicrobial agent for its ability to inhibit the growth of bacteria and fungi, making it a potential candidate for use in treating infections and promoting overall health.
Used in Agrochemical Industry:
EHPN is used as an anti-inflammatory agent for its potential utility in the treatment of inflammatory conditions, which can be beneficial in managing various diseases and disorders in agriculture.
Used in Research and Development:
EHPN is used as a subject of study for its potential applications in various industries due to its antimicrobial and anti-inflammatory properties, with the aim of further developing its uses and understanding its mechanisms of action.

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 109-77-3 malononitrile 
• 905406-44-2 C₁₇H₁₇NO₃ 

Relevant academic research and scientific papers

Knoevenagel condensation reaction on a new highly-efficient La2O2CO3-TiO2 mixed oxide catalyst: Composition-effects on C[dbnd]C bond formation

The highly efficient catalytic abilities of some mixed oxides are due to cooperative interactions between acid and base functional groups present in their active sites. New La2O2CO3-TiO2 mixed oxide catalysts wi

Highly Active Copper(I)-Chalcogenone Catalyzed Knoevenagel Condensation Reaction Using Various Aldehydes and Active Methylene Compounds

First copper(I) chalcogenones catalysed Knoevenagel Condensation reactions have been reported. No illustration of the utilization of this copper-chalcogenone complex class in Knoevenagel Condensation catalysis can be found. Thus, copper(I) bis(benzimidazole-2-chalcogenone) catalysts [Cu(L1)4]+BF4? (1) and [Cu(L2)4]+BF4? (2) (L1 = bis(1-isopropyl-benzimidazole-2-selone)-3-ethyl; L2 = bis(1-isopropyl-benzimidazole-2-thione)-3-ethyl) have been utilized as catalysts in the Knoevenagel Condensation reactions. These copper(I) chalcogenone catalysts have shown high efficiency for the catalytic Knoevenagel Condensation of aryl aldehydes and active methylene compounds. In particular, complex 2, exhibit the best catalytic activities. The scope of the catalytic reactions has been investigated with 22 different molecules. The excellent catalytic activity has been depicted for various types of substrates with either electron-rich or deficient aryl aldehydes. The present investigation features relatively mild reaction conditions with good functional group tolerance and excellent yields. Graphic Abstract: The first copper(I)-chalcogenone complexes catalysed Knoevenagel Condensation reactions?have also been investigated, and revealed the best catalytic activities. [Figure not available: see fulltext.]

Chemoselective reaction of malononitrile with imine-ones and antifungal potential of products

Condensation of malononitrile with 1-[4-(benzylideneamino.-phenyl]efhanones 1-10, the compounds containing both carbonnitrogen and carbon-oxygen double bonds, in equimolar ratio results in the formation of solid products, identified as-benzylidenemalononitrile and its derivatives 1a-10a on the basis of elemental analysis and spectral studies. The reaction of 1-10 with two moles of malononitrile also yields the same products 1a-10a by a chemoselective attack of malononitrile on carbonnitrogen double bond only rather than on both the reactive centres. The synthesized compounds 1a-10a have been evaluated for antifungal potential against Alternaria alternata, Colletotrichum capsici, Fusarium oxysporum, Myrothecium roridum and Ustilago tritici. Some of the compounds have been found to possess promising antifungal potential against the test fungi.

Structural studies on bioactive compounds. 32. Oxidation of tyrphostin protein tyrosine kinase inhibitors with hypervalent iodine reagents

Hydroxylated styrenes (tyrphostins) undergo oxidation by hypervalent iodine oxidants such as [(diacetoxy)iodo]benzene (DAIB) to give a range of products depending on the structure of the phenolic substrate, the solvent, the oxidant stoichiometry, and the purification strategy. Conditions have been developed to modify the phenolic component of the tyrphostin without affecting the appended substituted-vinyl moiety. Novel products include: unstable 2-acyloxy-2-methoxy-4-(substituted-vinyl)cyclohexadienones and their rearrangement products 2-acyloxy-4-hydroxy-3-methoxy-1-(substituted- vinyl)benzenes; phenyliodoniophenolates and their rearrangement products iodophenoxytyrphostins; and 3,3'-dialkoxy-2,2'-dihydroxy-5,5'-di(substituted- vinyl)biphenyls. None of these oxidation products displayed enhanced activity in vitro in the NCI 60-cell line panel or in a panel of human breast cancer cell lines, compared to their tyrphostin precursors. The inhibitory activity of three representative tyrphostins (3e,n, 28) was not modulated by aerobic/anaerobic conditions in MCF-7 and MDA 468 cells and was independent of EGFR status in clones of ZR75B cells transfected with this receptor. Basal growth of MCF-7 cells was unaffected by co-administration of the growth factors EGF, TGF-α, IGF-I, and IGF-II, and the new agents did not inhibit EGFR and c-erbB2 autophosphorylation in cell lysates from MDA 468 or SkBr3 cells, respectively, suggesting that receptor tyrosine kinases are not targets for these compounds. Growth stimulation by the tyrphostin 3n in the ER+ breast cell lines MCF-7, T47D, and ZR75-1 was abolished by 1 μM tamoxifen, suggesting that this compound has estrogen agonist activity.