157283-66-4 Usage
Description
(+)-Cloprostenol isopropyl ester is a synthetic analog of prostaglandin F2α (PGF2α), specifically the optically active, 15(R) enantiomer of cloprostenol. It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol isopropyl ester is 200 times more potent than PGF2α in terminating pregnancy when administered subcutaneously at a daily dose of 0.125 μg/kg. Additionally, it has been shown to be a potent inhibitor of rat adipose precursor differentiation in primary cultures, with an IC50 value of 3 x 10^-12 M. The isopropyl ester form of cloprostenol is more lipid-soluble, enhancing its bioavailability and effectiveness.
Uses
Used in Pharmaceutical Industry:
(+)-Cloprostenol isopropyl ester is used as a pharmaceutical agent for its potent luteolytic properties, making it effective in terminating pregnancy in rats and hamsters. Its high potency and reduced side effects compared to PGF2α make it a preferred choice in this application.
Used in Veterinary Medicine:
In the veterinary medicine industry, (+)-Cloprostenol isopropyl ester is used as a luteolytic agent to control the reproductive cycles of animals, such as cows and sheep, by inducing the regression of the corpus luteum.
Used in Research Applications:
(+)-Cloprostenol isopropyl ester is used as a research tool for studying the effects of prostaglandins and their receptors, particularly the FP receptor, in various biological processes and disease models.
Used in Drug Delivery Systems:
The increased lipid solubility of (+)-Cloprostenol isopropyl ester makes it a suitable candidate for the development of novel drug delivery systems, potentially improving its bioavailability and therapeutic outcomes in various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 157283-66-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,2,8 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157283-66:
(8*1)+(7*5)+(6*7)+(5*2)+(4*8)+(3*3)+(2*6)+(1*6)=154
154 % 10 = 4
So 157283-66-4 is a valid CAS Registry Number.
157283-66-4Relevant articles and documents
Synthesis of (±) travoprost and its analogs
Mudduluru, Harikrishna,Hindupur, Rama M.,Dubey, Pramod K.,Madhavaram, Shankar,Tatini, Lakshmikumar,Subbaraju, Gottumukkala V.
experimental part, p. 234 - 241 (2012/04/18)
A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.
Storage-stable prostaglandin compositions
-
, (2008/06/13)
The use of polyethoxylated castor oils in prostaglandin compositions greatly enhances the prostaglandin's chemical stability.
