1573119-01-3Relevant academic research and scientific papers
Synthesis and antimycobacterial activity of disubstituted benzyltriazoles
Smit, Frans J.,Seldon, Ronnett,Aucamp, Janine,Jordaan, Audrey,Warner, Digby F.,N’Da, David D.
, p. 2279 - 2293 (2019)
The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the treatment of this plight. In search
Facile One-Pot Synthesis of 1,2,3-Triazoles Featuring Oxygen, Nitrogen, and Sulfur Functionalized Pendant Arms
Mendoza-Espinosa, Daniel,Negron-Silva, Guillermo,Lomas-Romero, Leticia,Gutierrez-Carrillo, Atilano,Santillan, Rosa
, p. 807 - 817 (2014/03/21)
A practical and efficient one-pot synthesis of novel 1,2,3-triazoles featuring nitrogen, oxygen, and sulfur functionalized pendant arms has been developed. The click reaction of mono-propargyl derivatives supported by aniline, thiophenol, and benzyl alcohol, with sodium azide and p-substituted benzyl halogenides, renders a series of N-substituted-1,2,3-triazoles in good yields under mild reaction conditions. The catalyst system was based in Cu(OAc)2·H2O, sodium L-ascorbate, and 1,10-phenanthroline monohydrate, and all reactions were performed in a mixture H2O-ethanol (4:1 v/v). Additionally, the preparation of bis-1,2,3-triazoles supported by di-propargylated aniline was carried out, demonstrating the versatility of the present methodology. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
