15733-09-2Relevant academic research and scientific papers
Chemoselective α-sulfidation of amides using sulfoxide reagents
Leypold, Mario,D'Angelo, Kyan A.,Movassaghi, Mohammad
supporting information, p. 8802 - 8807 (2020/11/03)
The direct α-sulfidation of tertiary amides using sulfoxide reagents under electrophilic amide activation conditions is described. Employing convenient and readily available reagents, selective functionalization takes place to generate isolable sulfonium
Methanesulfinylation of Benzyl Halides with Dimethyl Sulfoxide
Fu, Duo,Dong, Jun,Du, Hongguang,Xu, Jiaxi
, p. 2752 - 2758 (2020/01/31)
A phenyltrimethylammonium tribromide-mediated nucleophilic substitution/oxygen transformation reaction of benzyl halides with DMSO has been developed. In this transition-metal-free reaction, DMSO acts as not only a solvent but also a "S(O)Me" source, thus providing a convenient method for the efficient and direct synthesis of various benzyl methyl sulfoxides.
An Efficient Asymmetric Oxidation of Sulfides to Sulfoxides
Pitchen, P.,Dunach, E.,Deshmukh, M. N.,Kagan, H. B.
, p. 8188 - 8193 (2007/10/02)
The Sharpless reagent for asymmetric epoxidation was modified by addition of 1 mol equiv of H2O to give a new homogenous reagent (Ti(O-i-Pr)4/diethyl tartrate/H2O/t-BuOOH = 1:2:1:1).This reagent cleanly oxidizes prochiral functionalized sulfides into optically active sulfoxides.The observed ee mainly ranged between 75 and 90percent for alkyl aryl sulfoxides and 50-71percent for dialkyl sulfoxides.A strong temperature dependence on ee was also observed in the asymmetric oxidation of methyl p-tolyl sulfoxide.
