157330-72-8Relevant academic research and scientific papers
Piperidine derivatives as 5-HT4 receptor antagonists
-
, (2008/06/13)
Compounds of formula (I): STR1 wherein Xg is O, S, SO, SO2, CH2, CH, N or NR wherein R is hydrogen or C1-6 alkyl; A is a saturated or unsaturated polymethylene chain of 2-4 carbon atoms; R1g and R2g are hydrogen or C1-6 alkyl; R3g is hydrogen, halo, C1-6 alkyl, amino, nitro or C1-6 alkoxy; R4g is hydrogen, halo, C1-6 alkyl or C1-6 alkoxy, Y is O or NH, or CO--Y together are a heterocyclic bioisostere; Z is of sub-formula: STR2 wherein --(CH2)n1 is attached at carbon; and n1 is 0, 1, 2, 3 or 4; q is 0, 1, 2 or 3; Ra is a straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by R7 wherein R7 is 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, or R7 is C2-7 alkoxycarbonyl or secondary or tertiary hydroxy substituted C1-6 alkyl; and R6 is hydrogen or C1-6 alkyl; are useful as 5HT4 receptor antagonists.
