157335-97-2

Basic information

• Product Name: 5-BROMO-4,6-DIMETHYLPYRIMIDINE
• Synonyms: 5-BROMO-4,6-DIMETHYLPYRIMIDINE;EOS-61560
• CAS NO: 157335-97-2
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Halides;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 157335-97-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 162-164 °C
• Boiling Point: 240.6°C at 760 mmHg
• Flash Point: 99.3°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 0.0581mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: 2-8°C
• PKA: 1.52±0.26(Predicted)
• CAS DataBase Reference: 5-BROMO-4,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-4,6-DIMETHYLPYRIMIDINE(157335-97-2)
• EPA Substance Registry System: 5-BROMO-4,6-DIMETHYLPYRIMIDINE(157335-97-2)

Safety Data

• Hazardous Substances Data: 157335-97-2(Hazardous Substances Data)

Usage

Uses

5-Bromo-4,6-dimethylpyrimidine is a useful synthetic intermediate. It is used to prepare indanyloxydihydrobenzofuranylacetic acids as GPR40 receptor modulators.

InChI:InChI=1/C6H7BrN2/c1-4-6(7)5(2)9-3-8-4/h3H,1-2H3

Upstream product

• 157335-96-1 2-hydrazino-4,6-dimethyl-5-bromopyrimidine 
• 7781-20-6 5-bromo-4,6-dimethyl-2(1H)-pyrimidinone 
• 4786-72-5 2-Chloro-5-bromo-4,6-dimethyl-pyrimidine 

Downstream Products

• 1609259-55-3 4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenol 
• 1609259-56-4 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-c]pyridine 
• 1609259-57-5 {4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridin-1-yl}methanol 
• 1609258-90-3 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrrolo[3,2-c]pyridine 
• 1609259-58-6 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine 
• 1609258-91-4 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine 
• 1609259-75-7 4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenol 
• 1609259-76-8 4-[4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenoxy]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine 
• 1609258-93-6 4-[4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine 
• 1609581-39-6 5-(2-chloro-4-methoxyphenyl)-4,6-dimethylpyrimidine 
• 1609581-51-2 3-chloro-4-(4,6-dimethylpyrimidin-5-yl)phenol 
• 1609581-29-4 2-(4,6-dimethylpyrimidin-5-yl)-5-(furo[3,2-c]pyridin-4-yloxy)benzyl acetate 

Relevant articles and documents

Synthesis and Proton NMR Spectra of the Monomethyl- and Dimethylpyrimidine-5-carboxylic Acids. Regioselective Covalent Hydration at the 2- and 4-Ring Positions

Pyrimidine-5-carboxylic acid, its 2-methyl, 4-methyl, 2,4-dimethyl- and 4,6-dimethyl derivatives have been synthesized and their proton nmr spectra measured in dilute aqueous acid.Pyrimidine-5-carboxylic acid (1a, R2,4,6=H) was found to afford an equilibrium mixture of covalent hydrates at both the 2- and 4-ring positions (2a and 3a).The 2-methyl derivative (1b, R2=Me, R4,6=H) undergoes hydration exclusively at the 4-position (2b) while the 4-methyl derivative (1c, R2,6=H, R4=Me) hydrates selectively at only the 2-position (3c).Covalent hydration was notobservable for either the 2,4-dimethyl- (1d, R2,4=Me, R6=H) or 4,6-dimethyl- (1e, R2=H, R4,6=Me) pyrimidinecarboxylic acids.The synthetic routes to these substances are described and the degree of hydration for each compound was measured.