157335-97-2

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-4,6-DIMETHYLPYRIMIDINE is used as a synthetic intermediate for the preparation of indanyloxydihydrobenzofuranylacetic acids. These acids are known as GPR40 receptor modulators, which play a crucial role in the treatment of type 2 diabetes and other related metabolic disorders. The compound's unique structure allows for the development of new drugs that can effectively target and modulate the GPR40 receptor, leading to improved therapeutic outcomes for patients suffering from these conditions.
In addition to its application in the pharmaceutical industry, 5-BROMO-4,6-DIMETHYLPYRIMIDINE may also find use in other chemical synthesis processes, where its unique molecular structure can be leveraged to create novel compounds with potential applications in various fields. However, the specific uses in these industries may vary and would require further research and development to fully understand their potential benefits and limitations.

InChI:InChI=1/C6H7BrN2/c1-4-6(7)5(2)9-3-8-4/h3H,1-2H3

Upstream product

• 157335-96-1 2-hydrazino-4,6-dimethyl-5-bromopyrimidine 
• 7781-20-6 5-bromo-4,6-dimethyl-2(1H)-pyrimidinone 
• 4786-72-5 2-Chloro-5-bromo-4,6-dimethyl-pyrimidine 

Downstream Products

• 157335-93-8 4,6-dimethylpyrimidine-5-carboxylic acid 
• 1609259-42-8 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-fluorophenoxy]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[3,2-c]pyridine 
• 1609259-54-2 5-(4-methoxy-2-methylphenyl)-4,6-dimethylpyrimidine 
• 1609259-84-8 4-(4,6-dimethylpyrimidin-5-yl)-2,3-difluorophenol 
• 1609581-39-6 5-(2-chloro-4-methoxyphenyl)-4,6-dimethylpyrimidine 
• 1609581-51-2 3-chloro-4-(4,6-dimethylpyrimidin-5-yl)phenol 
• 1609581-29-4 2-(4,6-dimethylpyrimidin-5-yl)-5-(furo[3,2-c]pyridin-4-yloxy)benzyl acetate 
• 1609577-07-2 4-[4-(4,6-dimethylpyrimidin-5-yl)-3-methylphenoxy]furo[3,2-c]pyridine 
• 1609258-93-6 4-[4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenoxy]-1H-pyrazolo[4,3-c]pyridine 
• 1609259-76-8 4-[4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenoxy]-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridine 
• 1609259-75-7 4-(4,6-dimethyl-1-oxidopyrimidin-5-yl)-3-methylphenol 

Relevant academic research and scientific papers

Synthesis and Proton NMR Spectra of the Monomethyl- and Dimethylpyrimidine-5-carboxylic Acids. Regioselective Covalent Hydration at the 2- and 4-Ring Positions

Pyrimidine-5-carboxylic acid, its 2-methyl, 4-methyl, 2,4-dimethyl- and 4,6-dimethyl derivatives have been synthesized and their proton nmr spectra measured in dilute aqueous acid.Pyrimidine-5-carboxylic acid (1a, R2,4,6=H) was found to afford an equilibrium mixture of covalent hydrates at both the 2- and 4-ring positions (2a and 3a).The 2-methyl derivative (1b, R2=Me, R4,6=H) undergoes hydration exclusively at the 4-position (2b) while the 4-methyl derivative (1c, R2,6=H, R4=Me) hydrates selectively at only the 2-position (3c).Covalent hydration was notobservable for either the 2,4-dimethyl- (1d, R2,4=Me, R6=H) or 4,6-dimethyl- (1e, R2=H, R4,6=Me) pyrimidinecarboxylic acids.The synthetic routes to these substances are described and the degree of hydration for each compound was measured.