157337-06-9Relevant academic research and scientific papers
Synthesis of methyl 2-(fluoromethyl)-3-fluoroalanine
Davis,Reddy,Bental,Deutsch
, p. 701 - 702 (1994)
The title compound 1b, an important intracellular pH indicator, is conveniently prepared in 44% overall yield from 1,3-difluoro-2-propanol (2). Key steps in this synthesis include oxidation of 2 to 1,3-difluoroacetone (3) in near quantitative yield using KMnO4/CuSO4 and the addition of trimethylsilyl cyanide to a phenyl glycinol protected imine. The efficiency of this process was enhanced further by use of crude reaction mixtures of their solutions.
