157338-49-3

Basic information

• Product Name: Piperidine, 4-[(4-nitrophenyl)methyl]-1-(trifluoroacetyl)-
• CAS NO: 157338-49-3
• Molecular Formula: C14H15F3N2O3
• Molecular Weight: 316.28
• Mol File: 157338-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperidine, 4-[(4-nitrophenyl)methyl]-1-(trifluoroacetyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 4-[(4-nitrophenyl)methyl]-1-(trifluoroacetyl)-(157338-49-3)
• EPA Substance Registry System: Piperidine, 4-[(4-nitrophenyl)methyl]-1-(trifluoroacetyl)-(157338-49-3)

Safety Data

• Hazardous Substances Data: 157338-49-3(Hazardous Substances Data)

Upstream product

• 31252-42-3 4-benzylpyperidine 
• 407-25-0 trifluoroacetic anhydride 
• 157338-47-1 1-(trifluoroacetyl)-4-benzylpiperidine 

Downstream Products

• 77093-81-3 4-(4’-nitrobenzyl)piperidine 
• 333987-11-4 tert-butyl 4-(4-morpholin-4-ylbenzyl)piperidine-1-carboxylate 
• 221532-96-3 4-(4-aminobenzyl)piperidine-1-carboxylic acid tert-butyl ester 
• 333987-05-6 tert-butyl 4-(4-nitrobenzyl)piperidine-1-carboxylate 

Relevant articles and documents

Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors

To prepare thiol-reactive ifenprodil derivatives designed as potential probes for cysteine-substituted NR2B containing NMDA receptors, electrophilic centers were introduced in different areas of the ifenprodil structure. Intermediates and final compounds were evaluated by binding studies and by electrophysiology to determine the structural requirements for their selectivity. The reactive compounds were further tested for their stability and for their reactivity in model reactions; some were found suitable as structural probes to investigate the binding site and the docking mode of ifenprodil in the NR2B subunit.