157360-23-1

Basic information

• Product Name: 4,6-Di-tert-butyl-2,2-dipentyl-2,3-dihydrobenzofuran-5-ol
• Synonyms: BO-653
• CAS NO: 157360-23-1
• Molecular Formula: C₂₆H₄₄O₂
• Molecular Weight: 388.63938
• Mol File: 157360-23-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4,6-Di-tert-butyl-2,2-dipentyl-2,3-dihydrobenzofuran-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Di-tert-butyl-2,2-dipentyl-2,3-dihydrobenzofuran-5-ol(157360-23-1)
• EPA Substance Registry System: 4,6-Di-tert-butyl-2,2-dipentyl-2,3-dihydrobenzofuran-5-ol(157360-23-1)

Safety Data

• Hazardous Substances Data: 157360-23-1(Hazardous Substances Data)

Upstream product

• 1252024-18-2 C₂₆H₄₆O₃ 
• 173662-47-0 4-acetoxy-3,5-di-tert-butyl-2-(1-hydroxy-2-pentylheptyl)phenol 
• 157360-60-6 4-acetoxy-2-aminomethyl-3,5-di-tert-butylphenol 
• 157360-29-7 5-acetoxy-4,6-di-tert-butyl-2-hydroxybenzaldehyde 
• 75169-17-4 4-acetoxy-3,5-di-tert-butylanisole 
• 32102-41-3 4-acetoxy-3,5-di-tert-butylphenol 
• 489-01-0 2,6-Di-t-butyl-4-methoxyphenol 
• 390393-99-4 5-acetoxy-4,6-di-tert-butyl-2,3-dihydro-2,2-dipenthylbenzofuran 

Relevant articles and documents

A new strategy for the synthesis of 4,6-di-tert-butyl-2,2-dipentyl-2,3- dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant

An efficient alternative route to 4,6-di-tert-butyl-2,2-dipentyl-2,3- dihydro-5-benzofuranol (BO-653), a potent antiatherogenic antioxidant, has been developed by the application of the base-promoted dienone- phenol rearrangement reaction. A decisive effect of MgBr2 in the reaction of Grignard reagents is also described.

Process for preparation of a benzofuran derivative

An industrially useful process for producing benzofuran derivatives of formula (1) by formylating a compound of formula (2) (where A1 is a protective group), followed by reaction with a compound of formula (4) (where X1 is a halogen atom), then performing a cyclizing reaction and subsequently performing a reaction for hydroxyl group deprotection.

Prophylactic/therapeutic agents for atherosclerosis

PCT No. PCT/JP98/01861 Sec. 371 Date Nov. 8, 1999 Sec. 102(e) Date Nov. 8, 1999 PCT Filed Apr. 23, 1998 PCT Pub. No. WO98/50025 PCT Pub. Date Nov. 12, 1998Herein disclosed are prophylactic/therapeutic agents for atherosclerosis containing a compound of general formula (1): wherein R1 represents a hydrogen atom or an acyl group, R2 represents a lower alkyl group, R3 represents a hydrogen atom or a lower alkyl group, and R4, R5 and R6 represent a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or an aryl group, or R2 and R4 together with the oxygen atom may form a furan or dihydrofuran ring, or R5 and R6 may combine to form a cycloalkyl group or a heterosubstituted cycloalkyl group in which one or more methylene groups of the cycloalkyl group are replaced by oxygen, sulfur or alkyl-substituted nitrogen atoms, a possible optically active isomer or a pharmaceutically acceptable salt thereof, as an active ingredient.