157372-99-1

Basic information

• Product Name: 1-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 1-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-Cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid
• CAS NO: 157372-99-1
• Molecular Formula: C₁₃H₁₀FNO₃
• Molecular Weight: 247.2218032
• EINECS: -0
• Mol File: 157372-99-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(157372-99-1)
• EPA Substance Registry System: 1-Cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid(157372-99-1)

Safety Data

• Hazardous Substances Data: 157372-99-1(Hazardous Substances Data)

Usage

Uses

1-Cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid can be used to prepare iminoquinolinecarboxamides. It can also be used as a reagent to prepare 1-alkyl-1,4-dihydro-4-imino-3-quinolinecarboxylic acid derivatives.

Upstream product

• 7664-93-9 sulfuric acid 
• 157372-98-0 ethyl 1-cyclopropyl-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylate 
• 72482-64-5 2,4-difluorobenzoyl chloride 
• 1048039-26-4 ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate 
• 436101-59-6 1-cyclopropyl-4-ethylimino-7-fluoro-1,4-dihydroquinoline-3-carboxylic acid 

Downstream Products

• 1616491-31-6 N-benzyl-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide 
• 436101-95-0 7-benzylamino-4-benzylimino-1-cyclopropyl-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity

Despite the fact that the introduction of a fluorine atom at the C-6 position has resulted in the evolution of fluoroquinolones, fluoroquinolone-induced cardiac toxicity has drawn considerable attention. In this context, desfluoroquinolone-based hybrids w

Polysubstituted quinolone compounds, and preparation method and use thereof

The invention provides polysubstituted quinolone compounds, and a preparation method and a use thereof, and concretely provides a polysubstituted quinolone compound represented by formula I, and optical isomers, pharmaceutically acceptable salts or solvates thereof. All groups in the formula I are defined in the description. The quinolone compound has excellent c-Met inhibition activity, and can be used for treating c-Met activity or expression level corrected diseases.

1-Alkyl-1,4-dihydro-4-iminoquinoline-3-carboxylic acids: Synthesis, structure and properties

1-Alkyl-1,4-dihydro-4-iminoquinoline-3-carboxylates undergo neutral hydrolysis (in H2O or H2O-EtOH mixtures) to yield water-soluble 4-iminoquinoline-3-carboxylic acids and the corresponding 4-oxo esters. Such 4-imino acids are also accessed by treating an appropriate 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid successively with thionyl chloride and an amine-H2O mixture, or from treatment of a 4-imino ester salt with aqueous amine. In the latter procedures 7-fluoro substituted substrates gave rise to 7-alkylamino derivatives even at room temperature. The title compounds are inferred to have an intramolecularly H-bonded charge transfer structure, and some of their chemical reactions and spectral (HRMS, 1H NMR) properties are described.