157373-27-8

Basic information

• Product Name: ethyl 2-[(2,6-dichloropyridin-3-yl)carbonyl]-3-ethoxyacrylate
• Synonyms: ethyl 2-[(2,6-dichloropyridin-3-yl)carbonyl]-3-ethoxyacrylate
• CAS NO: 157373-27-8
• Molecular Weight: 318.157
• Mol File: 157373-27-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 2-[(2,6-dichloropyridin-3-yl)carbonyl]-3-ethoxyacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(2,6-dichloropyridin-3-yl)carbonyl]-3-ethoxyacrylate(157373-27-8)
• EPA Substance Registry System: ethyl 2-[(2,6-dichloropyridin-3-yl)carbonyl]-3-ethoxyacrylate(157373-27-8)

Safety Data

• Hazardous Substances Data: 157373-27-8(Hazardous Substances Data)

Upstream product

• 58584-83-1 2,6-dichloronicotinoyl chloride 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 174727-36-7 ethyl 3-(2,6-dichloropyridin-3-yl)-3-oxopropanoate 

Downstream Products

• 175414-77-4 vosaroxin 
• 174726-87-5 ethyl 7-chloro-4-oxo-1-(1,3-thiazol-2-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylate 

Relevant articles and documents

Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives

A series of naphthyridinone derivatives based on 1a (a precursor of Voreloxin) were designed and synthesized. Seven compounds having >70% inhibition against HL60 at 30 μmol/L were further evaluated for their in vitro antitumor activity by SRB assay. Results reveal that thiazol-2-yl and 3-aminomethyl-4-benzyloxyimino-3-methylpyrrolidin-1-yl groups are optimal at the N-1 and C-7 positions of naphthyridinone core, respectively. 10j exhibits broad-spectrum activity (IC50: 100-fold more potent than the two references against eight of these cell lines.

1,8-Naphthyridine-3-carboxamide derivatives with anticancer and anti-inflammatory activity

A number of 1-propargyl-1,8-naphthyridine-3-carboxamide derivatives (15-35) have been synthesized and screened for their in vitro cytotoxicity and anti-inflammatory activity. Compounds 22, 31 and 34 have shown high cytotoxicity against a number of cancer cell lines, while compound 24 showed significant anti-inflammatory activity.