157373-97-2

Basic information

• Product Name: 2-BROMO-3-PYRIDYL TRIFLUOROMETHANESULFO&
• Synonyms: 2-BROMO-3-PYRIDYL TRIFLUOROMETHANESULFO&;2-bromo-3-pyridyl triflate;2-bromo-3-pyridyl trifluoromethanesulfonate
• CAS NO: 157373-97-2
• Molecular Formula: C₆H₃BrF₃NO₃S
• Molecular Weight: 306.06
• Mol File: 157373-97-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 321°C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 1.7869 g/mL at 25 °C
• Vapor Pressure: 0.000574mmHg at 25°C
• Refractive Index: n20/D 1.4806
• PKA: -2.85±0.10(Predicted)
• CAS DataBase Reference: 2-BROMO-3-PYRIDYL TRIFLUOROMETHANESULFO&(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-PYRIDYL TRIFLUOROMETHANESULFO&(157373-97-2)
• EPA Substance Registry System: 2-BROMO-3-PYRIDYL TRIFLUOROMETHANESULFO&(157373-97-2)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 157373-97-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H3BrF3NO4S/c7-5-4(2-1-3-11-5)14-16(12,13)15-6(8,9)10/h1-3H

Upstream product

• 6602-32-0 2-bromo-pyridin-3-ol 
• 358-23-6 trifluoromethylsulfonic anhydride 

Downstream Products

• 2098215-65-5 2-cyclopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 579475-72-2 3-[3-(2-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester 
• 579475-66-4 3-[3-(2-cyclopropyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester 
• 222168-98-1 3-Phenylethynyl-pyridine-2-carbaldehyde oxime 
• 222168-09-4 3-Phenylethynyl-pyridine-2-carbaldehyde 
• 222167-93-3 2-chloro-4-(4-chlorophenyl)thiazole 
• 318-69-4 Benzothieno<3,2-b>pyridine 
• 1264712-14-2 trifluoromethanesulfonic acid 2-(2-fluorophenyl)pyridin-3-yl ester 

Relevant articles and documents

Rapid Bergman cyclization of 1,2-diethynylheteroarenes

The synthesis and cyclization of acyclic quinoxaline, pyridine, and pyrimidine enediynes (1-3) are described. These compounds were prepared using palladium(0) coupling of trimethylsilyl acetylene to o-dihalo- or o- halotriflic heteroarenes. All compounds were prepared in modest to good yields. The enediynes prepared were shown to undergo Bergman cyclization. Kinetics over a minimum of 3 half-lives were used to construct ]Arrhenius plots. Pyrimidine 3 was found to have an activation energy of 16.1 kcal/mol. Cyclization of the closest known aromatic analogue, o-diethynylbenzene (15), has E(a) = 25.1 kcal/mol (Grissom, J. W.; Calkins, T. L.; McMillen, H. A.; Jiang, Y. J. Org. Chem. 1994, 59, 5833-5835). Pyridine 2 and quinoxaline 1 gave activation energies of 21.5 and 33.6 kcal/mol, respectively. The results illustrate that heteroarenes can be used to activate Bergman cyclization. We expect these compounds to play an important role in furthering the understanding of Bergman cyclization and in aiding the development of new biologically significant enediynes.

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

4-Piperidinecarboxamide modulators of vanilloid VR1 receptor

This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.