157394-82-6Relevant academic research and scientific papers
Total Synthesis of the Ethanol Inducible, Proinflammatory Autacoid 3(S)-Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues
Chauhan, Kamlesh,Bhatt, Rama K.,Falck, J. R.,Capdevila, Jorge H.
, p. 1825 - 1828 (2007/10/02)
3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9. - Key Words: eicosanoid, chelati
3-Hydroxyleukotriene B4 (3-OH-LTB4): Total synthesis and stereochemical assignment
Bhatt, Rama K.,Chauhan, Kamlesh,Wheelan, Pat,Murphy, Robert C.,Falck
, p. 5050 - 5056 (2007/10/02)
The asymmetric total synthesis of 3-hydroxyleukotriene B4 (3-OH-LTB4), an ethanol-inducible proinflammatory antacoid, was achieved using a triply convergent strategy for the sequential union of propargylic arsonium salt 3 with pyrano
