1574159-22-0Relevant academic research and scientific papers
Synthesis of enantiomerically pure 4-polyfluoromethyl-4-hydroxy- homoprolines by intramolecular cyclization of 6-amino-5-polyfluoromethyl-hex-2- enoic acids
Shaitanova, Elena N.,Gerus, Igor I.,Kukhar, Valery P.,Haufe, Günter
, p. 8 - 11 (2014)
An effective route to racemic and enantiopure 4-polyfluoromethyl-4-hydroxy- homoprolines was developed based on readily available 2-alkoxyvinyl- polyfluoromethyl ketones. Key step of the synthesis was a diastereoselective heterocyclization of 6-amino-5-polyfluoromethyl-hex-2-enoic acids under acidic conditions. The absolute configuration of the stereogenic centers was determined by X-ray.
