157430-57-4Relevant academic research and scientific papers
Flexible and stereoselective construction of polypropionate chains from enantiomerically pure γ-hydroxy-α,β-unsaturated sulfones
Dominguez, Esteban,Carretero, Juan C.
, p. 7557 - 7566 (1994)
Following an homologation sequence the readily available enantiomerically pure γ-hydroxy vinyl sulfone 2 has been transformed, with complete control of the stereochemistry, into γ-hydroxy vinyl sulfones of polypropionate structure. The four stereotriads have been prepared by stereoselective additions of organometallics to the vinyl sulfone moiety and by stereoselective reduction of β-hydroxyketones. In a similar way, these triads are the substrates for the stereoselective introduction of the fourth consecutive asymmetric center.
