157431-09-9Relevant articles and documents
SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE
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Paragraph 0081-0085, (2020/09/15)
A method for synthesizing levomethadone hydrochloride including producing (R)-2-(dimethylamino)propan-1-ol by reducing N,N-dimethyl-D-alanine using borax, forming (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochloride by chlorinating the (R)-2-(dimethylamino)propan-1-ol, synthesizing levomethadone nitrile hydrochloride by mixing the (R)-1-chloro-N,N-dimethylpropane-2-amine and diphenylacetonitrile with potassium t-butoxide and producing levomethadone hydrochloride by exposing the levomethadone nitrile hydrochloride to a Grignard reagent.
Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba
Kang, Kyo Bin,Ming, Gao,Kim, Geum Jin,Ha, Thi-Kim-Quy,Choi, Hyukjae,Oh, Won Keun,Sung, Sang Hyun
, p. 90 - 95 (2016/03/04)
Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication.
METABOTROPIC GLUTAMATE RECEPTORS 5 MODULATORS AND METHODS OF USE THEREOF
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Page/Page column 121-122, (2012/12/13)
Compounds that modulate GluR5 activity and methods of using the same are disclosed.