157433-36-8

Basic information

• Product Name: 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE;3-(2-Chlorophenyl)propanal;Benzenepropanal, 2-chloro-
• CAS NO: 157433-36-8
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Mol File: 157433-36-8.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 238.573°C at 760 mmHg
• Flash Point: 117.087°C
• Appearance: /
• Density: 1.139g/cm³
• Vapor Pressure: 0.042mmHg at 25°C
• Refractive Index: 1.527
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE(157433-36-8)
• EPA Substance Registry System: 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE(157433-36-8)

Safety Data

• Hazardous Substances Data: 157433-36-8(Hazardous Substances Data)

Usage

General Description

3-(2-chloro-phenyl)-propionaldehyde, also known as 2-chloro-3-phenylpropionaldehyde, is an organic compound with the chemical formula C9H9ClO. It is a pale yellow liquid that is commonly used as a fragrance ingredient in perfumes and other personal care products due to its floral and fruity scent. 3-(2-CHLORO-PHENYL)-PROPIONALDEHYDE is also used as an intermediate in the production of pharmaceuticals and other organic compounds. 3-(2-chloro-phenyl)-propionaldehyde is classified as a hazardous substance and should be handled with care due to its potential irritant and sensitizing properties.

InChI:InChI=1/C9H9ClO/c10-9-6-2-1-4-8(9)5-3-7-11/h1-2,4,6-7H,3,5H2

Upstream product

• 35573-93-4 3-chloro-1,1-diethoxy-propane 
• 694-80-4 2-bromo-1-chlorobenzene 
• 201230-82-2 carbon monoxide 
• 2039-87-4 2-chlorostyrene 
• 20461-86-3 2,2-diethoxy acetic acid 
• 1794-45-2 2-chlorocinnamaldehyde 
• 704-96-1 trans-2-chlorocinnamic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 6282-87-7 3-(2-chlorophenyl)-propanol 
• 615-41-8 2-iodochlorobenzene 
• 107-18-6 allyl alcohol 

Downstream Products

• 6282-87-7 3-(2-chlorophenyl)-propanol 
• 1160858-26-3 C₁₃H₁₅ClO₃ 
• 1391979-83-1 N-{4-(3-chlorophenyl)-5-[(2-chlorophenyl)methyl]-1,3-thiazol-2-yl}-2-[4-(ethylsulfonyl)phenyl]acetamide 
• 1391980-19-0 5-(2-chlorobenzyl)-4-(3-chlorophenyl)thiazol-2-amine 
• 1391980-17-8 3-(2-chlorophenyl)-1-(3-chlorophenyl)propan-1-one 
• 1391980-16-7 3-(2-chlorophenyl)-1-(3-chlorophenyl)propan-1-ol 
• 1221430-99-4 6-(2-chloro-benzyl)-2-(4-methyl-thiazol-2-yl)thieno[2,3-d]pyrimidin-4-ylamine 
• 1221185-51-8 3-[4-amino-6-(2-chloro-benzyl)thieno[2,3-d]pyrimidin-2-yl]benzonitrile 
• 1221431-03-3 6-(2-chloro-benzyl)-2-(5-methyl-furan-2-yl)thieno[2,3-d]pyrimidin-4-ylamine 
• 1221185-62-1 2-amino-5-(2-chloro-benzyl)thiophene-3-carbonitrile 
• 1223578-79-7 (S)-3-(2-chlorophenyl)-N-(2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-propan-1-amine 
• 148717-49-1 tecalcet 

Relevant articles and documents

Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

MICROCAPSULES AND PROCESSES FOR THEIR PREPARATION

The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.

Enantioselective Synthesis of 4-Methyl-3,4-dihydroisocoumarin via Asymmetric Hydroformylation of Styrene Derivatives

Enantioenriched aldehydes are produced through asymmetric hydroformylation of styrene derivatives using BIBOP-type ligands. The featured example is enantioselective synthesis of 4-methyl-3,4-dihydroisocoumarin, which was prepared in a 95.1:4.9 enantiomeric ratio from asymmetric hydroformylation of ethyl 2-vinylbenzoate followed by in situ lactonization during the reduction process. The conditions are compatible with both electron-rich and electron-poor substituents.