157444-69-4

Basic information

• Product Name: 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester
• Synonyms: 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester;Methyl 2-(4-(tert-butyl)phenyl)-2-Methylpropanoate
• CAS NO: 157444-69-4
• Molecular Formula: C15H22O2
• Molecular Weight: 234.33398
• Mol File: 157444-69-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester(157444-69-4)
• EPA Substance Registry System: 2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester(157444-69-4)

Safety Data

• Hazardous Substances Data: 157444-69-4(Hazardous Substances Data)

Usage

General Description

2-(4-tert-Butyl-phenyl)-2-Methyl-propionic acid Methyl ester is a chemical compound with the molecular formula C13H18O2. It is also known by the trade name Irganox 1300 and is commonly used as an antioxidant in a variety of industries, including food and cosmetics. It is a pale yellow liquid with a mild, fruity odor and is soluble in organic solvents. This chemical is known for its ability to prevent oxidation and extend the shelf life of products by inhibiting the formation of free radicals. It is considered to be safe for use in these applications, with minimal risk of adverse effects.

Upstream product

• 23426-63-3 2-bromo-2-methylpropionic acid methyl ester 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 547-63-7 Methyl isobutyrate 
• 1070-89-9 sodium hexamethyldisilazane 

Relevant articles and documents

Palladium-catalyzed α-arylation of esters and protected amino acids [2]

-

α-arylation of esters catalyzed by the Pd(I) dimer [P(t-Bu)3Pd(μ-Br)]

-

Efficient synthesis of α-aryl esters by room-temperature palladium-catalyzed coupling of aryl halides with ester enolates

A catalytic amount of Pd(dba)2 ligated by either carbene precursor N,N′-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium (1) or P(t-Bu)3 mediated the coupling of aryl halides and ester enolates to produce α-aryl esters in high yields at room temperature. The reaction was highly tolerant of functionalities and substitution patterns on the aryl halide. Improved protocols for the selective monoarylation of tert-butyl acetate and the efficient arylation of α,α-disubstituted esters were developed with LiNCy2 as base and P(t-Bu)3 as ligand. In addition, tert-butyl esters, such as those of Naproxen and Flurbiprofen, were prepared from tert-butyl propionate and aryl bromides in high yields in the presence of Pd(dba)2 and the hindered, saturated heterocyclic carbene ligand precursor.