1574491-96-5Relevant academic research and scientific papers
A homologation approach to the synthesis of difluorinated cycloalkynes
Sletten, Ellen M.,De Almeida, Gabriela,Bertozzi, Carolyn R.
, p. 1634 - 1637 (2014/04/17)
Difluorinated cyclooctynes are important reagents for labeling azido-biomolecules through copper-free click chemistry. Here, a safe, scalable synthesis of a difluorinated cyclooctyne is reported, which involves a key homologation/ring-expansion reaction. Sequential ring expansions were also employed to synthesize and study a novel difluorinated cyclononyne.
