157458-10-1Relevant academic research and scientific papers
Acid-promoted DNA-cleaving activities and total synthesis of varacin C
Lee, Alex H. F.,Chen, Jian,Liu, Dongsheng,Leung, Thomas Y. C.,Chan, Albert S. C.,Li, Tianhu
, p. 13972 - 13973 (2007/10/03)
The first total synthesis of the antibiotic varacin C has been accomplished. In addition, it has been demonstrated that this antibiotic exhibits potent antitumor activity and is capable of causing efficient DNA cleavage under acidic conditions. Copyright
Synthesis and structural properties of the benzopentathiepins varacin and isolissoclinotoxin A
Ford,Narbut,Belli,Davidson
, p. 5955 - 5960 (2007/10/02)
The unique pentathiepin-containing compounds varacin (1) and isolissoclinotoxin A (3) have each been synthesized in eight steps from vanillin. Formation of the pentathiepin ring in varacin was accomplished by treatment of the dithiolate anion, generated f
Lissoclinotoxins: Antibiotic polysulfur derivatives from the tunicate Lissoclinum perforatum. Revised structure of lissoclinotoxin A
Litaudon, Marc,Trigalo, Francois,Martin, Marie-Therese,Frappier, Francois,Guyot, Michele
, p. 5323 - 5334 (2007/10/02)
Lissoclinotoxin B, a new pentathiepin derivative, was isolated from the tunicate Lissoclinum perforatum. Structure elucidation of this compound is described based on spectroscopic data, together with a revised structure for lissoclinotoxin A. A synthesis
