1574707-46-2Relevant academic research and scientific papers
N-Phenyl-substituted carbene precursors and their silver complexes: Synthesis, characterization and antimicrobial activities
Goek, Yetkin,Akkoc, Senem,Albayrak, Sevil,Akkurt, Mehmet,Tahir, Muhammad Nawaz
, p. 244 - 251 (2014)
A series of unsymmetrically substituted N-heterocyclic carbene (NHC) precursors (1a, 1b, 1c, 1d, 1e) were synthesized from the reaction of N-phenylbenzimidazole with various alkyl halides. These compounds were used to synthesize NHC-silver(I) complexes (2a, 2b, 2c, 2d, 2e). The five new 1-phenyl-3-alkylbenzimidazolium salts (1a, 1b, 1c, 1d, 1e) and their NHC-silver complexes (2a, 2b, 2c, 2d, 2e) were characterized by the 1H NMR, 13C NMR and FT-IR spectroscopic methods and elemental analysis techniques. Also, the two NHC-silver complexes 2b and 2c were characterized by single-crystal X-ray crystallography, which confirmed the linear C - Ag - Cl arrangements. The antibacterial activities of the NHC precursor and NHC-silver complexes were tested against three Gram-positive bacterial strains (Bacillus subtilis, Listeria monocytogenes and Staphylococcus aureus) and three Gram-negative bacterial strains (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) using the microdilution broth method. The NHC-silver complexes showed higher antibacterial activity than the NHC precursors. In addition, silver complexes 2a, 2b, 2c, 2d showed high antibacterial activity against the Gram-positive bacteria L. monocytogenes and S. aureus compared to the standard, tetracycline. Copyright
